Development of a resonant-type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals

作者：Kimura Hiroyuki; Yagi Yusuke; Ohneda Noriyuki; Odajima Hiro; Ono Masahiro; Saji Hideo^*

来源：Journal of Labelled Compounds and Radiopharmaceuticals, 2014, 57(12): 680-686.

DOI：10.1002/jlcr.3232

• resonant-type microwave reactor
• positron emission tomography radiochemistry
• F-18-fluorination
• [F-18]FES
• [F-18]MPPF
• [F-18]SFB

Microwave technology has been successfully applied to enhance the effectiveness of radiolabeling reactions. The use of a microwave as a source of heat energy can allow chemical reactions to proceed over much shorter reaction times and in higher yields than they would do under conventional thermal conditions. A microwave reactor developed by Resonance Instrument Inc. (Model 520/521) and CEM (PETWave) has been used exclusively for the synthesis of radiolabeled agents for positron emission tomography by numerous groups throughout the world. In this study, we have developed a novel resonant-type microwave reactor powered by a solid-state device and confirmed that this system can focus microwave power on a small amount of reaction solution. Furthermore, we have demonstrated the rapid and facile radiosynthesis of 16-[F-18]fluoroestradiol, 4-[F-18]fluoro-N-[2-(1-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinylbenzamide, and N-succinimidyl 4-[F-18]fluorobenzoate using our newly developed microwave reactor.

• 出版日期2014-10