Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms

作者：Kim Eun Ran; Yang Mun Hee; Lim Yeun Jung; Lee Jin Hee; Chang Dong Kyung; Kim Young Ho; Son Hee Jung; Kim Jae J; Rhee Jong Chul; Kim Jin Yong^*

来源：Gut and Liver, 2013, 7(5): 519-523.

DOI：10.5009/gnl.2013.7.5.519

• Plasminogen activator inhibitor 1
• Colorectal neoplasms

Background/Aims: Plasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas. Methods: We reviewed the medical records of 3,136 subjects who underwent colonoscopy as a screening exam. The subjects were classified into a case group with adenomas (n=990) and a control group (n=2,146). Plasma PAI-1 levels were categorized into three groups based on tertile. Results: The plasma levels of PAI-1 were significantly higher in adenoma cases than in controls (p=0.023). The prevalence of colorectal adenomas increased significantly with increasing levels of PAI-1 (p=0.038). In the adenoma group, advanced pathologic features, size, and number of adenomas did not differ among the three groups based on tertiles for plasma PAI-1 levels. Using multivariate analysis, we found that plasma level of PAI-1 was not associated with the risk of colorectal adenomas (p=0.675). Adjusted odds ratios for colorectal adenomas according to increasing plasma levels of PAI-1 were 0.980 (95% confidence interval [CI], 0.768 to 1.251) for the second-highest plasma level and 1.091 (95% CI, 0.898 to 1.326) for the highest level, compared with the lowest levels. Conclusions: These results suggest that elevated plasma PAI-1 levels are not associated with the risk of colorectal neoplasms.

• 出版日期2013-9