Physical Crosslinked Poly(N-isopropylacrylamide)/Nano-Hydroxyapatite Thermosensitive Composite Hydrogels

作者：Wang, Shuo; Zhang, Zhaofu; Zhang, Qihai^*; Li, Lifang^*

来源：Journal of Inorganic and Organometallic Polymers and Materials, 2018, 28(5): 2069-2079.

DOI：10.1007/s10904-018-0893-9

• N-Isopropyl acrylamide
• Nano-hydroxyapatite
• Thermosensitive composite hydrogels
• Hemocompatibility
• Injectable materials

Injectable and thermosensitive poly(N-isopropylacrylamide) (PNIPA)/nano-hydroxyapatite (nano-HA) composite hydrogels were synthesized by physical crosslinking of N-isopropylacrylamide with nano-HA as cross-linker to improve the mechanical property of hydrogels and avoid the use of chemical cross-linker. Internal morphology, thermosensitive, rheological, swelling, and hemocompatibility properties of the prepared hydrogels were investigated. The PNIPA/HA composite hydrogels had a phase transition from sol to gel, and the lowest critical solution temperature was about 32.5 A degrees C. The PNIPA/HA composite hydrogels had regular pore structures and the nano-HA dispersed well throughout the network. Differential scanning calorimetry and thermogravimetric analysis showed that the addition of nano-HA had no significant effect on the LCST and thermal stability of the PNIPA/HA hydrogels. When the temperature was above 32.5 A degrees C, the storage modulus (G') and complex viscosity increased with the increasing nano-HA content. All PNIPA/HA composite hydrogels possessed the thinning behavior. The PNIPA/HA hydrogels exhibited a good water absorption capacity and the swelling ratio decreased with the increasing nano-HA content. As revealed by biocompatibility results, PNIPA/HA composite hydrogels were considered to be a non-hemolytic biomaterial. Therefore, PNIPA/HA hydrogels can be used as injectable materials for the potential applications of science and technology, such as tissue engineering scaffolds.

• 出版日期2018-9
• 单位泰安市中心医院; 山东农业大学