Activity against Streptococcus pneumoniae of the Essential Oil and 5-(3-Buten-1-ynyl)-2, 2 '-bithienyl Isolated from Chrysactinia mexicana Roots

作者：Guevara Campos Barbara Missiam Mezari; Torres Cirio Anabel; Rivas Galindo Veronica Mayela; Salazar Aranda Ricardo; Waksman de Torres Noemi; Alejandro Perez Lopez Luis

来源：Natural Product Communications, 2011, 6(7): 1035-1038.

• Chrysactinia mexicana
• essential oil
• 5-(-buten-1-ynyl)-2, 2 '-bithienyl
• antimicrobial activity
• Streptococcus pneumoniae

The essential oil of Chrysactinia mexicana retrieved from the root bark was characterized by gas chromatography coupled to a mass detector. The compounds silphiperfol-5-ene, 7-epi- silphiperfol-5-ene, modheph-2-ene, alpha-isocomene, beta-isocomene and methyl-linoleate were identified. The principal compound (76.42%) could not be identified by the library and was further isolated through a reverse phase C-18 chromatography followed by silica gel chromatography and identified as 5-(3-buten-1-ynyl)-2,2'-bithienyl. Both the oil and the isolated compound were tested for their antimicrobial activity against two strains of Streptococcus pneumoniae resistant to beta-lactam antibiotics. MICs were 250 mu g/mL and 125 mu g/mL respectively. This is the first report about extraction of oil and compound 5-(3-buten-1-ynyl)-2, 2'-bithienyl from roots of Chrysactinia mexicana as well as the determination of antimicrobial activity against S. pneumoniae.

• 出版日期2011-7