Phosgene-free synthesis of N-aryl-N′-(4-pyridinyl)ureas via selenium-catalyzed oxidative carbonylation of 4-aminopyridine with aromatic amines

作者：Zhang, Xiaopeng^*; Li, Zhengwei; Wang, Yan; Dong, Shuxiang; Niu, Xueli; Zhang, Guisheng^*

来源：ARKIVOC, 2016, 2016(5): 197-209.

DOI：10.3998/ark.5550190.p009.683

• selenium
• carbonylation
• nitrogen heterocycles
• N-aryl-N '-(4-pyridinyl) ureas
• phosgene-free method

A facile, phosgene-free approach with high atom economy has been developed for the synthesis of N-aryl-N'-(4-pyridinyl) ureas. With cheap selenium as the catalyst, carbon monoxide (instead of phosgene) as the carbonyl reagent, N-aryl-N'-(4-pyridinyl) ureas can be obtained in a one-pot manner mostly in moderate to good yields via oxidative cross-carbonylation of 4-aminopyridine with a variety of aromatic amines in the presence of oxygen under atmospheric pressure. The mechanism for the synthesis of N-aryl-N'-(4-pyridinyl) ureas is also proposed.

• 出版日期2016
• 单位河南师范大学