Heme oxygenase-1 expression in chronic rhinosinusitis with eosinophilic infiltration

作者：Kawano Kenji; Kusunoki Takeshi; Ono Noritsugu; Yao Toru; Saito Tatsuya; Yokoi Hidenori; Ikeda Katsuhisa^*

来源：Auris Nasus Larynx, 2012, 39(4): 387-392.

DOI：10.1016/j.anl.2011.10.001

• Heme oxygenase (HO)-1
• Nasal polyps
• Chronic rhinosinusitis
• Eosinophilic infiltration
• Macrophage

Objectives: Chronic rhinosinusitis (CRS) with eosinophilic infiltration is a type of intractable rhinosinusitis often associated with asthma. The oxidants are well known to induce aggravate asthma. Heme oxygenase-1 (HO-1), a cytoprotective enzyme against oxidant, has been extensively studied in airway diseases. However, no study that observed HO-1 in both epithelial and subepithelial tissues of CRS has been reported. %26lt;br%26gt;Methods: Part of each specimen derived from the nasal polyps of CRS with and without eosinophilic infiltration was promptly fixed for hematoxylin-eosin staining and immunohistochemical analysis for HO-1 and macrophages. %26lt;br%26gt;Results: We found that the expression of HO-1 in the epithelial layers of CRS without eosinophilic infiltration was significantly enhanced as compared with that of CRS with eosinophilic infiltration. On the other hand, the number of macrophages with HO-1 positive reactions was significantly greater in CRS with eosinophilic infiltration compared with CRS without eosinophilic infiltration. %26lt;br%26gt;Conclusions: Our study suggests that both a reduction of HO-1 expression in epithelial cells and an increase of infiltration of macrophages positive for HO-1 are related to the epithelial damage of CRS with eosinophilic infiltration.

• 出版日期2012-8