Advances in 2-phenylethanol production from engineered microorganisms

作者：Wang, Yuqin; Zhang, Hao; Lu, Xinyao; Hong Zong; Bin Zhuge^*

来源：Biotechnology Advances, 2019, 37(3): 403-409.

DOI：10.1016/j.biotechadv.2019.02.005

• 2-Phenylethanol
• Biosynthesis
• Metabolic engineering
• Yeast
• Escherichia coli

2-Phenylethanol (2-PE) is an important flavor ingredient with a rose-like odor. Due to concerns about the toxic byproducts potentially found in 2-PE from chemical synthesis, consumers prefer the natural aroma compound, promoting the biosynthesis of 2-PE. Various microorganisms produce 2-PE naturally with low yield. Recent metabolic engineering strategies in yeasts and Escherichia colt have achieved great success in improving 2-PE bioproduction, including the alleviation of feed-back inhibition, improvement of precursor transport, enhancing activities of crucial enzymes, and reduction of by-products. Here, we review the metabolic engineering strategies applied to microorganisms for increasing bioproduction of 2-PE, address current problems, and propose further improvements.

• 出版日期2019-6
• 单位江南大学