Activin B inhibits lipolysis in 3T3-L1 adipocytes

作者：Magnusson Bjorn; Svensson Per Arne^*; Carlsson Lena M S; Sjoholm Kajsa

来源：Biochemical and Biophysical Research Communications, 2010, 395(3): 373-376.

DOI：10.1016/j.bbrc.2010.04.022

• Activin B
• Lipolysis
• Adipocytes

Activin B. consisting of two inhibin beta B (INHBB) subunits, is a hormone known to affect gonadal function, reproduction and fetal development. We have reported that INHBB and activin B receptors are highly expressed in adipocytes suggesting that activin B may have local effects in adipose tissue. In this study, we investigate the effect of activin B on lipolysis, measured as release of non-esterified fatty acids and free glycerol. Recombinant activin B decreased lipolysis in a concentration-dependent manner and increased intracellular triglyceride content in 3T3-L1 adipocytes. siRNA-mediated knockdown of INHBB expression increased lipolysis, and this effect was abolished by addition of recombinant activin B. In line with its inhibitory effect on lipolysis, activin B caused a down regulation of the expression of adipose triglyceride lipase and hormone sensitive lipase, key genes involved in lipolysis. In summary, we suggest that activin B is a novel adipokine that inhibits lipolysis in a paracrine or autocrine manner.

• 出版日期2010-5-7
• 单位河北医科大学