Association analysis between endothelial function related factors and coronary artery stenosis degree in coronary heart disease patients with type 2 diabetes mellitus

作者：Li Quanmin^*; Zhang Zhifang; Du Ruiqin; Hu Xiaoqiang; Yan Yan; Gao Qing; Fan Yanting

来源：Journal of Pediatric Endocrinology & Metabolism, 2012, 25(7-8): 711-716.

DOI：10.1515/jpem-2012-0159

• cell adhesion molecule 1
• coronary angiography
• coronary heart disease
• nonocyte chemotactic protein 1
• soluble intercellular vascular cell adhesion molecule 1
• type 2 diabetes mellitus
• von Willebrand factor

Objective: To investigate the relationship between soluble intercellular adhesion molecule (sICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), monocytes chemotactic protein (MCP-1), von Willebrand factor (vWF), and coronary artery stenoses degree in coronary heart disease (CHD) within type 2 diabetes mellitus (T2DM) patients.
Methods: A total of 92 subjects were treated with coronary angiography (CAG), including 62 subjects with CHD. The individuals were divided into three groups, group A (32 patients with CHD and T2DM), group B (30 patients with CHD but no T2DM) and group C (30 patients with no CHD and T2DM). All patients were treated with a Gensini coronary angiography check. The correlations between sICAM-1, VCAM-1, MCP-1 and vWF in peripheral blood and coronary artery stenosis degree were analyzed.
Results: The average score of coronary artery stenosis degree was 30.75 +/- 12.67 in group A, which was significantly higher than group B (11.20 +/- 7.51) and group C (2.40 +/- 1.23) (p<0.01). The mean levels of sICAM-1, VCAM-1, MCP-1 and vWF in serum showed that group A was significantly higher than group B and group C (p<0.01), and also that group B was higher than group C. There were significant positive correlations between the degree of coronary artery stenosis and the mean level of sICAM-1, VCAM-1, MCP-1, vWF in group A (p<0.01), but these were not shown in group B and group C (p>0.05).
Conclusions: Association analysis shown that the level of sICAM-1, VCAM-1, MCP-1 and vWF elevated in CHD with T2DM patients. Vascular endothelial dysfunction could be caused to the coronary artery stenosis pathophysiological process. Results from this study suggested that sICAM-1, VCAM-1, MCP-1 and vWF may contribute to the occurrence and development of vascular lesions in T2DM. These endothelial function related factors could be acceptable as a prediction and testing index of vascular complications in T2DM.

• 出版日期2012-8