科研之友
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摘要
Functional and structural maturation of networks comprised of discrete regions is an important aspect of brain development The default-mode network (DMN) is a prominent network which includes the posterior cingulate cortex (PCC). medial prefrontal cortex (mPFC), medial temporal lobes (MTL). and angular gyrus (AG) Despite increasing interest in DMN function, little is known about its maturation from childhood to adulthood Here we examine developmental changes in DMN connectivity using a multimodal imaging approach by combining resting-state fMRI, voxel-based morphometry and diffusion tensor imaging-based tractography We found that the DMN undergoes significant developmental changes in functional and structural connectivity, but these changes are not uniform across all DMN nodes Convergent structural and functional connectivity analyses suggest that PCC-mPFC connectivity along the cingulum bundle is the most immature link in the DMN of children Both PCC and mPFC also showed gray matter volume differences, as well as prominent macrostructural and microstructural differences in the dorsal cingulum bundle linking these regions Notably, structural connectivity between PCC and left MTL was either weak or non-existent in children, even though functional connectivity did not differ from that of adults These results imply that functional connectivity in children can reach adult-like levels despite weak structural connectivity. We propose that maturation of PCC-mPFC structural connectivity plays an important role in the development of self-related and social-cognitive functions that emerge during adolescence. More generally, our study demonstrates ho
- 出版日期2010-8-1
