alpha-Methyltyrosine, a tyrosine hydroxylase inhibitor, decreases stress response in zebrafish (Danio rerio)

作者：Idalencio Renan; de Alcantara Barcellos Heloisa Helena; Kalichak Fabiana; Santos da Rosa Joao Gabriel; Oliveira Thiago Acosta; de Abreu Murilo Sander; Fagundes Michele; Dametto Fernanda; Marcheto Leticia; de Oliveira Caio Maximino; Gil Barcellos Leonardo Jose

来源：General and Comparative Endocrinology, 2017, 252: 236-238.

DOI：10.1016/j.ygcen.2017.07.012

• Dopaminergic control
• AMPT
• Stress response
• Cortisol
• Hypothalamus-pituitary-adrenal axis

In this article, we show that the tyrosine hydroxylase inhibitor alpha-Methyl-L-tyrosine (AMPT) decreased the responsiveness of the zebrafish stress axis to an acute stressful challenge. These effects were specific for responses to stimulation, since unstimulated (basal) cortisol levels were not altered by AMPT. Moreover, AMPT decreased the stress response 15 min after stimulation, but not after that time period. To our knowledge, this is the first report about the effects of AMPT on the neuroendocrine axis of adult zebrafish in acute stress responses. Overall, these results suggest a mechanism of catecholamine-glucocorticoid interplay in neuroendocrine responses of fish, pointing an interesting avenue for physiological research, as well as an important endpoint that can be disrupted by environmental contamination. Further experiments will unravel the mechanisms by which AMPT blocked the cortisol response.

• 出版日期2017-10-1