African Mitochondrial DNA Subhaplogroups and Peripheral Neuropathy during Antiretroviral Therapy

作者：Canter Jeffrey A; Robbins Gregory K; Selph Doug; Clifford David B; Kallianpur Asha R; Shafer Robert; Levy Shawn; Murdock Deborah G; Ritchie Marylyn D; Haas David W; Hulgan Todd^*

来源：Journal of Infectious Diseases, 2010, 201(11): 1703-1707.

DOI：10.1086/652419

Susceptibility to peripheral neuropathy during antiretroviral therapy with nucleoside reverse-transcriptase inhibitors was previously associated with a European mitochondrial DNA (mtDNA) haplogroup among non-Hispanic white persons. To determine whether nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy was related to mtDNA variation in non-Hispanic black persons, we sequenced mtDNA of participants from AIDS Clinical Trials Group study 384. Of 156 non-Hispanic black persons with genomic data, 51 (33%) developed peripheral neuropathy. In a multivariate model, African mtDNA subhaplogroup L1c was an independent predictor of peripheral neuropathy (odds ratio, 3.7 [95% confidence interval, 1.1-12.0]). An African mtDNA subhaplogroup is for the first time implicated in susceptibility to nucleoside reverse-transcriptase inhibitor-associated toxicity.

• 出版日期2010-6-1