Association of an oral formulation of angiotensin-(1-7) with atenolol improves lipid metabolism in hypertensive rats

作者：Santos Cynthia F F; Santos Sergio H S; Ferreira Adaliene V M; Botion Leida M; Santos Robson A S^*; Campagnole Santos Maria Jose

来源：Peptides, 2013, 43: 155-159.

DOI：10.1016/j.peptides.2013.03.009

• Angiotensin-(1-7)
• Mas receptor
• Atenolol
• Dyslipidemia
• SHR
• Renin-angiotensin system

The beta-adrenergic blockers and antagonists of the renin-angiotensin system (RAS) are among the drugs that present better results in the control of cardio-metabolic diseases. The aim of the present study was to evaluate the effect of the association of the beta-blocker, atenolol, and an oral formulation of Ang-(1-7) on lipid metabolism in spontaneously hypertensive rats (SHR). The main results showed that SHR treated with oral formulation of Ang-(1-7) in combination to atenolol have an improvement of lipid metabolism with a reduction of total plasma cholesterol, improvement of oral fat load tolerance and an increase in the lipolytic response stimulated by the beta-adrenergic agonist, isoproterenol, without modification of resting glucose or insulin sensitivity in adipocytes. In conclusion, we showed that administration of an Ang-(1-7) oral formulation in association with a beta-blocker induces beneficial effects on dyslipidemia treatment associated with hypertension.

• 出版日期2013-5