Depression and quality of life in monogenic compared to idiopathic, early-onset Parkinson%26apos;s disease

作者：Kasten Meike^*; Kertelge Lena; Tadic Vera; Brueggemann Norbert; Schmidt Alexander; van der Vegt Joyce; Siebner Hartwig; Buhmann Carsten; Lencer Rebekka; Kumar Kishore R; Lohmann Katja; Hagenah Johann; Klein Christine

来源：Movement Disorders, 2012, 27(6): 754-759.

DOI：10.1002/mds.24999

• nonmotor symptoms of Parkinson%26apos
• s disease
• early-onset PD
• monogenic PD
• quality of life
• depression

Quality of life (QoL) is decreased in PD and is linked with depression and anxiety. However, little is known about QoL in monogenic PD. Subjects with mutations in PD genes were recruited from ongoing family and genetic studies (manifesting carriers, n = 23; nonmanifesting carriers, n = 19). For comparison purposes, we included patients with idiopathic PD (IPD; n = 128; early onset, n = 38; late onset, n = 90), healthy controls (n = 127), and data on depressive symptoms of 144 patients with major depression (treated controls). Depression affected 31% of early-onset PD cases, 21% of late-onset cases, and 44% of manifesting carriers of mutations in PD genes, but was rare in the nonmanifesting carriers (7%) and healthy controls (5%). Subjects with Parkinson-associated depression reported fewer feelings of guilt or self-doubt than treated controls, but the occurrence of suicidal ideation was associated with severity of depression only. Social phobia (P = 0.018) and agoraphobia (P = 0.059) were more common in manifesting carriers than in any other group. QoL was decreased in the Parkinson groups, particularly in the early-onset cases (P %26lt; 0.001), and QoL correlated with depression in all analyses. In our study, monogenic and IPD cases were comparable in QoL and depression characteristics. The QoL and, possibly, overall prognosis of all PD patients can be improved by appropriate attention and treatment for depression, sleep impairments, and anxiety, even if the treatment of the motor problems cannot be further optimized.

• 出版日期2012-5
• 单位河北医科大学