Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the nucleus raphe magnus to participate in pain modulation

作者：Yang Jun^*; Yuan Huifeng; Liu Wenyan; Song Chaoyou; Xu Hongtao; Wang Gen; Song Cai; Ni Na; Yang Daiwei; Lin Baocheng

来源：Peptides, 2009, 30(9): 1679-1682.

DOI：10.1016/j.peptides.2009.05.026

• Arginine vasopressin
• Pain modulation
• Hypothalamic paraventricular nucleus
• Nucleus raphe magnus

Hypothalamic paraventricular nucleus (PVN) is one of the main sources of arginine vasopressin (AVP) synthesis and secretion. AVP is the most important bioactive substance in PVN regulating pain process. Our pervious study has pointed that pain stimulation induced AVP increase in the nucleus raphe magnus (NRM), which plays a role in pain modulation. The present study was designed to investigate the source of AVP in the rat NRM during pain process using the methods of nucleus push-pull perfusion and radioimmunoassay. The results showed that pain stimulation increased the AVP concentration in the NRM perfusion liquid, PVN cauterization inhibited the role that pain stimulation induced the increase of AVP concentration in the NRM perfusion liquid, and PVN microinjection of L-glutamate sodium, which excited the PVN neurons, could increase the AVP concentration in the NRM perfusion liquid. The data suggested that AVP in the PVN might be transferred to the NRM to participate in pain modulation.

• 出版日期2009-9
• 单位中国人民解放军第二军医大学; 河北医科大学; 济宁医学院