A Chiral-Pool-Based Approach to the Core Structure of (+)-Hyperforin

作者：Richard Jean Alexandre; Chen David Y K^*

来源：European Journal of Organic Chemistry, 2012, 2012(3): 484-487.

DOI：10.1002/ejoc.201101629

• Natural products
• Total synthesis
• Polycycles
• Chiral pool

Asymmetric entry to the bicyclic core structure of (+)-hyperforin is presented. The developed synthetic strategy features a carefully orchestrated stereochemical relay from the single chiral center residing within (-)-Wieland-Miescher ketone and an intramolecular aldol reaction to cast the [3.3.1] bicyclic scaffold found in a diverse array of polycyclic polyprenylated acylphloroglucinols.

• 出版日期2012-1