A new antibacterial chromone derivative from mangrove-derived fungus Penicillium aculeatum (No. 9EB)

作者：Huang, Huarong^*; Liu, Ting; Wu, Xiaoen; Guo, Junxi; Lan, Xiong; Zhu, Qin; Zheng, Xi; Zhang, Kun

来源：Natural Product Research, 2017, 31(22): 2593-2598.

DOI：10.1080/14786419.2017.1283498

• Chromone derivative
• Penicillium sp
• mangrove-derived fungus
• antibacterial activity
• alpha-glucosidase inhibition

One chromone derivative, (2'S*)-2-(2'-hydroxypropyl)-5-methyl-7, 8-dihydroxy-chromone (1), together with three known compounds, bacillisporin A (2), bacillisporin B (3) and 5-carboxyphthalide (4) were obtained from the mangrove-derived fungus Penicillium aculeatum (No. 9EB). Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 2 and 3 exhibited potent inhibitory activity against Bacillus subtilis with the same MIC values of 0.13 +/- 0.02 mu M, whereas compound 1 showed antibacterial activity against Salmonell with an MIC value of 2.00 +/- 0.02 mu M. Compound 2 and 3 possessed significant inhibitory activity against alpha-glucosidase with IC50 values of 33.55 +/- 0.63 and 95.81 +/- 1.12 mu M, respectively.
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• 出版日期2017
• 单位广东工业大学