A reversible metal ion fueled DNA three-way junction molecular device for "turn-on and -off" fluorescence detection of mercury ions (II) and biothiols respectively with high selectivity and sensitivity

作者：Ma, Long^*; Wu, Guanrong; Li, Yufeng; Qin, Ping; Meng, Lingpei; Liu, Haiyan; Li, Yuyin; Diao, Aipo

来源：Nanoscale, 2015, 7(43): 18044-18048.

DOI：10.1039/c5nr04688b

• NUCLEIC-ACID
• COLORIMETRIC DETECTION
• CIRCULAR-DICHROISM
• AQUEOUS-MEDIA
• BEACON
• HG2+
• DESIGN
• DRIVEN
• HG(II)

We constructed a reversible molecular device in the nanoscale based on a DNA three-way junction (3WJ) fueled by Hg2+ binding and sequestration. It is highly responsive to external stimuli, which brings about optically detectable global structural changes. Such a DNA device can serve as a novel "turn-on and -off" fluorescent sensor for Hg2+ and biothiol detection with high selectivity and sensitivity.

• 出版日期2015
• 单位天津科技大学