Novel one pot synthesis of substituted quinazolin-4(3H)-ones and pyrazolo[4,3-d]pyrimidin-7(6H)-ones using copper iodide, azides and terminal alkynes

作者：Srishyalam V; Devanna N; Rao M V Basaveswara; Mulakayala Naveen^*

来源：Tetrahedron Letters, 2017, 58(30): 2889-2892.

DOI：10.1016/j.tetlet.2017.06.026

• Quinazolin-4(3H)-ones
• Pyrazolo[4,3-d]pyrimidin-7(6H)-ones
• Azides
• Copper iodide
• Terminal alkynes

A simple and highly efficient copper iodide catalyzed one-pot synthesis of 2-substituted quinazolin-4 (3H)-ones have been developed from anthranilamide, terminal alkynes and azides. A wide variety of alkynes were screened to understand the scope of this methodology. This method has been extended for the synthesis of 5-substituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones which are having potential applications in medicinal chemistry.

• 出版日期2017-7-26