Lanthanide nano-drums: a new class of molecular nanoparticles for potential biomedical applications

作者：Jones Richard A^*; Gnanam Annie J; Arambula Jonathan F; Jones Jessica N; Swaminathan Jagannath; Yang Xiaoping; Schipper Desmond; Hall Justin W; DePue Lauren J; Dieye Yakhya; Vadivelu Jamuna; Chandler Don J; Marcotte Edward M; Sesster Jonathan L; Ehrlich Lauren I R; Brown Katherine A

来源：Faraday Discussions, 2014, 175: 241-255.

DOI：10.1039/c4fd00117f

We are developing a new class of lanthanide-based self-assembling molecular nanoparticles as potential reporter molecules for imaging, and as multi-functional nanoprobes or nanosensors in diagnostic systems. These lanthanide "nano-drums" are homogeneous 4d-4f clusters approximately 25 to 30 angstrom in diameter that can emit from the visible to near-infrared (NIR) wavelengths. Here, we present syntheses, crystal structures, photophysical properties, and comparative cytotoxicity data for six nano-drums containing either Eu, Tb, Lu, Er, Yb or Ho. Imaging capabilities of these nano-drums are demonstrated using epifluorescence, total internal reflection fluorescence (TIRF), and two-photon microscopy. We discuss how these molecular nanoparticles can to be adapted for a range of assays, particularly by taking advantage of functionalization strategies with chemical moieties to enable conjugation to protein or nucleic acids.

• 出版日期2014
• 单位温州大学