A label-free electrical detection of exosomal microRNAs using microelectrode array

作者：Goda Tatsuro; Masuno Kozue; Nishida Junko; Kosaka Nobuyoshi; Ochiya Takahiro; Matsumoto Akira; Miyahara Yuji^*

来源：Chemical Communications, 2012, 48(98): 11942-11944.

DOI：10.1039/c2cc36111f

We report a method for detecting microRNAs encapsulated in exosomes using a microelectrode array in semiconductor-based potentiometry after RT-PCR. The inherent miniaturization of the electrical biosensor meets requirements for massively parallel analysis of circulating microRNA as a noninvasive biomarker.

• 出版日期2012