ULTRASOUND-MEDIATED SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN-2-(1H)-ONES (OR THIONES) WITH NaHSO4 center dot H2O

作者：Dilmaghani Karim Akbari; Zeynizadeh Behzad^*; Amirpoor Maryam

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2013, 188(11): 1634-1642.

DOI：10.1080/10426507.2013.777725

• 3
• 4-Dihydropyrimidin-2-(1H)-ones
• aldehydes
• -dicarbonyls
• NaHSO4 center dot H2O
• ultrasound

A fast and efficient Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-ones (or thiones) by the reaction of aromatic aldehydes, -dicarbonyls, and urea/thiourea using NaHSO4H2O/ultrasound system is presented. The reactions were carried out in refluxing n-hexane/CH3CN (2.5:0.5mL) to afford the products in excellent yields.

• 出版日期2013-11-1