Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory

作者：Ohkawa Noriaki; Saitoh Yoshito; Suzuki Akinobu; Tsujimura Shuhei; Murayama Emi; Kosugi Sakurako; Nishizono Hirofumi; Matsuo Mina; Takahashi Yukari; Nagase Masashi; Sugimura Yae K; Watabe Ayako M; Kato Fusao; Inokuchi Kaoru^*

来源：Cell Reports, 2015, 11(2): 261-269.

DOI：10.1016/j.celrep.2015.03.017

Memory is thought to be stored in the brain as an ensemble of cells activated during learning. Although optical stimulation of a cell ensemble triggers the retrieval of the corresponding memory, it is unclear how the association of information occurs at the cell ensemble level. Using optogenetic stimulation without any sensory input in mice, we found that an artificial association between stored, non-related contextual, and fear information was generated through the synchronous activation of distinct cell ensembles corresponding to the stored information. This artificial association shared characteristics with physiologically associated memories, such as N-methyl-D-aspartate receptor activity and protein synthesis dependence. These findings suggest that the association of information is achieved through the synchronous activity of distinct cell ensembles. This mechanism may underlie memory updating by incorporating novel information into pre-existing networks to form qualitatively new memories.

• 出版日期2015-4-14