Dengue epidemiology and pathogenesis: images of the future viewed through a mirror of the past

作者：Islam Rashedul; Salahuddin Mohammed; Ayubi Md Salahuddin; Hossain Tahmina; Majumder Apurba; Taylor Robinson Andrew W; Mahmud Al Rafat Abdullah^*

来源：VIROLOGICA SINICA, 2015, 30(5): 326-343.

DOI：10.1007/s12250-015-3624-1

• dengue
• epidemiology
• pathogenesis
• dengue vaccine
• vector control
• anti-viral
• animal model

Every year, millions of individuals throughout the world are seriously affected by dengue virus. The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern. Not only does dengue cause fatalities but it also has a profoundly negative economic impact. In recent decades, extensive research has been performed on epidemiology, vector biology, life cycle, pathogenesis, vaccine development and prevention. Although dengue research is still not at a stage to suggest definite hopes of a cure, encouraging significant advances have provided remarkable progress in the fight against infection. Recent developments indicate that both anti-viral drug and vaccine research should be pursued, in parallel with vector control programs.

• 出版日期2015-10