Acute aerocystitis in Piaractus mesopotamicus: Participation of eicosanoids and pro-inflammatory cytokines

作者：Claudiano Gustavo da Silva; Petrillo Thalita R; Manrique Wilson G; Castro Marcello P; Loureiro Bruna A; Marcusso Paulo F; Belo Marco A A; Moraes Julieta R E; de Moraes Flavio Ruas^*

来源：Fish & Shellfish Immunology, 2013, 34(5): 1057-1062.

DOI：10.1016/j.fsi.2013.01.006

• Inflammation
• Teleost
• Vascular alteration
• Chemical mediators
• Evans blue

A total of 360 pacus (Piaractus mesopotamicus) were used to study vascular permeability (VP) and inflammatory cell component (CC) in induced aerocystitis in P. mesopotamicus through inoculation of inactivated Aeromonas hydrophila, and the effect of steroidal and nonsteroidal anti-inflammatory drugs. It was observed that after inoculation of A. hydrophila, the maximum VP occurred 180 min post-stimulus (MPS). Pretreatment with anti-inflammatory drugs inhibited VP, and the inhibitory effect of dexamethasone was seen earlier than the effects caused by meloxicam and indomethacin. Inoculation of the bacterium caused a gradual increase in the accumulation of cells, which reached a maximum 24 h post-stimulus (HPS). Pretreatment with dexamethasone, indomethacin and meloxicam reduced the accumulation of lymphocytes, thrombocytes, granulocytes and macrophages. There was no significant difference between the different doses of the drugs tested. The results suggest that eicosanoids and pro-inflammatory cytokines participate in chemical mediation in acute inflammation in pacus.

• 出版日期2013-5