Blood natural killer cell cytotoxicity enhancement correlates with an increased activity in brain motor structures following chronic stimulation of the bed nucleus of the stria terminalis in rats

作者：Myslinska Dorota; Plucinska Karolina; Glac Wojciech; Wrona Danuta^*

来源：Brain Research Bulletin, 2012, 87(2-3): 212-220.

DOI：10.1016/j.brainresbull.2011.12.004

• Bed nucleus of the stria terminalis
• Electrical stimulation
• Natural killer cell cytotoxicity
• Large granular lymphocytes
• Fos expression
• Rats

The present study indicates that a chronic 14 day electrical stimulation of the bed nucleus of the stria terminalis (BST) increased blood but not spleen natural killer cell (NM) cytotoxicity and a large granular lymphocyte (LGL) number. These immune changes positively correlated with the increased activity in brain cortical and subcortical motor structures that influence the BST stimulation-induced behavioral response. No significant changes in blood and spleen leukocyte population numbers and plasma corticosterone concentration after the stimulation were found. The obtained results suggest that this immunoenhancing effect on blood NM cell function and number is dependent on the behavioral outcome of the BST stimulation rather than endocrine response.

• 出版日期2012-2-10