A New Method for the Synthesis of 1-Aryl-1,2,4-triazole Derivatives

作者：Matiychuk Vasyl S; Potopnyk Mykhaylo A; Luboradzki Roman; Obushak Mykola D^*

来源：Synthesis (Germany), 2011, 2011(11): 1799-1803.

DOI：10.1055/s-0030-1260026

• 1,2,4-triazoles
• diazonium salts
• ring-opening
• thiazolidine-2,4-dione
• heterocyclization

A new and convenient one-step recyclization method for the synthesis of ethyl 1-aryl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-3-carboxylates is reported. Various ethyl chloro(2-arylhydrazinylidene)ethanoates react with thiazolidine-2,4-dione in the presence of potassium hydroxide to produce the 1-aryl-1,2,4-triazole derivatives in moderate to good yields. The procedure is economical, environmentally friendly and simple to perform.

• 出版日期2011-6