A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: case report and review of literature

作者：Fedorenko Inna V; Evernden Brittany; Kenchappa Rajappa S; Sahebjam Solmaz; Ryzhova Elena; Puskas John; McIntosh Linda; Caceres Gisela; Magliocco Anthony; Etame Arnold; Harbour J William; Smalley Keiran S M^*; Forsyth Peter A

来源：Melanoma Research, 2016, 26(5): 481-486.

DOI：10.1097/CMR.0000000000000274

• circulating tumor cells
• leptomeningeal carcinomatosis
• metastasis
• uveal melanoma

Uveal melanoma is a rare subtype of melanoma, accounting for only 3-5% of all melanoma cases in the USA. Although fewer than 4% of uveal melanoma patients present with metastasis at diagnosis, approximately half will develop metastasis, more than 90% of which disseminate to the liver. Infrequently, a number of malignancies can lead to leptomeningeal metastases, a devastating and terminal complication. In this case report, we present an exceedingly rare case of a patient with uveal melanoma who developed leptomeningeal carcinomatosis as the sole site of metastasis. After conventional methods to diagnose leptomeningeal carcinomatosis fell short, a diagnosis was confirmed on the basis of identification and genomic analysis of melanoma circulating tumor cells in the cerebrospinal fluid.

• 出版日期2016-10