Acute Adrenal Failure Associated with Primary Antiphospholipid Syndrome and Homozygosity for MTHFR C677T

作者：Mavridis Anastasios; Skopeliti Marina; Galani Panagiota; Lafoyianni Sofia; Christopoulos Constantinos

来源：Internal Medicine, 2011, 50(23): 2923-2926.

DOI：10.2169/internalmedicine.50.6342

• adrenal failure
• adrenal hemorrhage
• primary antiphospholipid syndrome
• MTHFR mutations

A 47-year-old woman with a recent clinical diagnosis of acute cholecystitis developed acute adrenal failure. Initial computed tomograms of the abdomen showed bilateral adrenal swelling which evolved into bilateral adrenal hemorrhage on repeat examination a few days later. Laboratory investigations revealed a previously undiagnosed primary antiphospholipid syndrome and homozygosity for the MTHFR C677T mutation with hyperhomocysteinemia. This case highlights the protean clinical manifestations of adrenal vascular accidents and the need for a thorough search for underlying prothrombotic states in this setting.

• 出版日期2011