Asymmetric hydrosilylation of cyclohexa-1,3-diene with trichlorosilane by palladium catalysts coordinated with chiral phosphoramidite ligands

作者：Park Hoon Seo; Han Jin Wook^*; Shintani Ryo; Hayashi Tamio

来源：Tetrahedron: Asymmetry , 2013, 24(7): 418-420.

DOI：10.1016/j.tetasy.2013.02.002

Chiral phosphoramidite ligands prepared from (S)-binaphthol and various secondary amines were examined for the palladium-catalyzed asymmetric hydrosilylation of cyclohexa-1,3-diene with trichlorosilane. With a sterically demanding phosphoramidite bearing bis(diphenylmethyl)amine, the high enantiomeric excess of 87% was achieved, which is the highest enantioselectivity in the hydrosilylation of cyclohexadiene reported to date. The catalytic activity in the present hydrosilylation was high with all of the ligands employed, while the enantioselectivities varied dramatically depending on the dialkylamine moiety of the phosphoramidite ligand.

• 出版日期2013-4-15