Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NF kappa B-mediated increase of intracellular doxorubicin accumulation

作者：Lee Jung Seok; Hong Eock Kee^*

来源：International Journal of Oncology, 2011, 38(2): 401-408.

DOI：10.3892/ijo.2010.852

• Agaricus blazei
• doxorubicin
• apoptosis
• hepatocellular carcinoma
• NF kappa B

It has been demonstrated that the Agaricus blazei Murill (ABM) mushroom, which primarily consists of polysaccharides, possesses anti-tumor activities. However, the mechanisms by which ABM inhibits human hepatocellular carcinoma growth remain unknown. Our study demonstrates that ABM acts as an enhancer to sensitize doxorubicin (Dox)-mediated apoptotic signaling, and this sensitization can be achieved by enhancing intracellular Dox accumulation via the inhibition of NF kappa B activity. These findings suggest that ABM, when combined with low doses of Dox, has the potential to provide more efficient therapeutic effects against drug-resistant human hepatocellular carcinoma.

• 出版日期2011-2