A novel dosage form for buccal administration of bupropion

作者：Galvao Almeida Nilsa Maria; Lima Renata; Ribeiro Alves Thais Francine; Rebelo Marcia de Araujo; Severino Patricia; Chaud Marco Vinicius^*

来源：Brazilian Journal of Pharmaceutical Sciences, 2015, 51(1): 91-100.

DOI：10.1590/S1984-82502015000100010

• Bupropion/buccal administration
• Bilayer films/drugs rellease
• Drugs/controlled-release
• Tobacco/control

Bupropion is an antidepressant used in the treatment of smoking. The purpose of this study was to prepare controlled-release hydrogel films for buccal administration of bupropion and investigate its physicochemical and cytotoxic properties. The films were prepared from ultrapure sodium carboxymethylcellulose, hydroxypropylmethylcellulose K4M, and medium-viscosity chitosan. Evaluation of film physicochemical characteristics was based on scanning electron microscopy, bupropion content, mechanical strength (burst strength, relaxation, resilience, and traction), and cytotoxicity. Bupropion content in bilayer films was 121 mg per 9 cm(2). The presence of bupropion modified film mechanical strength, but did not compromise the use of this pharmaceutical form. As shown by the cytotoxicity results, films containing bupropion did not cause cellular damage. Bupropion administration in the form of hydrogel films is a potentially useful alternative in the treatment of smoking.

• 出版日期2015-3