Application of oxa-aza[3.3.3]propellanes in the diastereoselective synthesis of indeno[1,2-b]pyrroles bearing bistriazole unit

作者：Alizadeh, Abdolali^*; Abarghoei, Sara Bashi; Bayat, Fahimeh; Halvagar, Mohammadreza; Zhu, Long-Guan

来源：Tetrahedron, 2017, 73(39): 5800-5805.

DOI：10.1016/j.tet.2017.08.029

• Hydrazonoyl chloride
• Oxa-aza[3.3.3]propellane
• Indeno[1,2-b]pyrrole
• Triazole
• 1,3-Dipolar cycloaddition

A highly efficient procedure for the construction of indeno[1,2-b]pyrroles bearing bistriazole unit from hydrazonoyl chlorides and oxa-aza[3.3.3]propellanes in EtOH in the presence of Et3N is reported. The reaction is supposed to proceed through a 1,3-dipolar cycloaddition reaction and ring opening process. Two new cycles and four new C-N bonds are formed in this transformation. The reaction scope was explored with different substituents on both substrates.

• 出版日期2017-9-28
• 单位浙江大学