Multiscale Evolutionary Dynamics of Host-Associated Microbiomes

作者:Ferreiro Aura; Crook Nathan; Gasparrini Andrew J; Dantas Gautam*
来源:Cell, 2018, 172(6): 1216-1227.
DOI:10.1016/j.cell.2018.02.015

摘要

The composite members of the microbiota face a range of selective pressures and must adapt to persist in the host. We highlight recent work characterizing the evolution and transfer of genetic information across nested scales of host-associated microbiota, which enable resilience to biotic and abiotic perturbations. At the strain level, we consider the preservation and diversification of adaptive information in progeny lineages. At the community level, we consider genetic exchange between distinct microbes in the ecosystem. Finally, we frame microbiomes as open systems subject to acquisition of novel information from foreign ecosystems through invasion by outsider microbes.

  • 出版日期2018-3-8