A unique mechanism regulating gene expression in 1-cell embryos Ryoma YAMAMOTO(1)) and Fugaku AOKI(1))

作者：Yamamoto Ryoma; Aoki Fugaku^*

来源：Journal of Reproduction and Development, 2017, 63(1): 9-11.

DOI：10.1262/jrd.2016-133

• 1-Cell embryos
• Gene expression
• Transcription
• Zygote

After fertilization, the genome of zygotes is transcriptionally silent. The timing of the initiation of transcription is species-specific and occurs at the mid-1-cell stage in mice. Recent analyses using high-throughput sequencing (HTS) have identified thousands of genes transcribed at the 1-cell stage, and the pattern of expression among these genes appears to be unique. In this article, we show the result of an additional analysis using HTS data from a previous study, and present the hypothesis that an extremely loose chromatin structure causes promiscuous gene expression in 1-cell embryos.

• 出版日期2017-2