An enterovirus 71 strain causes skeletal muscle damage in infected mice

作者：Lin, Peixin; Gao, Lulu; Huang, Yeen; Chen, Qing; Shen, Hong^*

来源：International Journal of Clinical and Experimental Pathology, 2015, 8(4): 3460-3468.

• Enterovirus 71
• BALB/c mice
• histopathological examination
• skeletal muscle damage
• myotropism
• mitochondrial injury

Objective: To study the target organs for enterovirus 71 (EV71) in infected suckling mice. Methods: 5-day-old BALB/c suckling mice were infected with an EV71 strain. Tissues of the infected mice were processed for histopathological examination, including immunohistochemistry, in situ hybridization, ultrastructural observation. Results: Some mice developed limb paralysis, trouble walking and loss of balance. Results of the histopathological study showed that a large amount of EV71 existed in the skeletal muscle tissues, accounting for the damage of the skeletal muscles. Conclusion: The EV71 clinical isolate used in this study presented evident myotropism. Skeletal muscles are important target organs for EV71 in the infected suckling mice. To clarify the relationship between EV71 infection and muscle diseases may contribute to a better understanding of the pathogenesis of EV71.

• 出版日期2015
• 单位南方医科大学