Association of gastrointestinal involvement and depressive symptoms in patients with systemic sclerosis

作者：Bodukam Vijay; Hays Ron D; Maranian Paul; Furst Daniel E; Seibold James R; Impens Ann; Mayes Maureen D; Clements Philip J; Khanna Dinesh^*

来源：Rheumatology, 2011, 50(2): 330-334.

DOI：10.1093/rheumatology/keq296

• Scleroderma
• Systemic sclerosis
• Depression
• Center for Epidemiologic Studies Short Depression scale
• Gastrointestinal involvement
• Reflux
• Constipation
• University of California at Los Angeles Scleroderma Clinical trial Consortium Gastrointestinal Tract 2
• 0

Methods. One hundred and fifty-two patients with SSc completed the UCLA SCTC GIT 2.0 and the Center for Epidemiologic Studies Short Depression scale (CES-D10). Patients were divided into depressed (CES-D epsilon 10) or non-depressed group (CES-D < 10) and compared using t-test or chi-square test. Multiple linear regression was used to determine associations between GI scales and depressed mood (CES-D).
Results. Study participants were 84% female, 78% Caucasian and 40% had depressed mood (CES-D10 epsilon 10). Patients with depressed mood had statistically worse GI scale scores (except fecal soilage) and worse total GIT score (P < 0.05). In the multivariable model reflux and constipation scales were independently associated with worse CES-D scores (P = 0.01-0.06)
Conclusion. SSc-GIT involvement is associated with depressed mood. Reflux and constipation scales of UCLA-SCTC GIT 2.0 were independently associated with CES-D. Future studies should assess if treatment of GIT symptoms will improve depressed mood in patients with SSc-GIT.

• 出版日期2011-2