Association Between NFKB1 -94ins/delATTG Promoter Polymorphism and Cancer Risk: A Meta-Analysis

作者：Zou, Yan-Feng; Yuan, Feng-Lai; Feng, Xiao-Liang; Tao, Jin-Hui; Ding, Ning; Pan, Fa-Ming; Wang, Fang^*

来源：Cancer Investigation, 2011, 29(1): 78-85.

DOI：10.3109/07357907.2010.535054

• NF-KAPPA-B
• FUNCTIONAL INSERTION/DELETION POLYMORPHISM
• GENE INCREASES SUSCEPTIBILITY
• TUMOR-NECROSIS-FACTOR
• COLORECTAL-CANCER
• NO ASSOCIATION
• CHROMOSOMAL LOCALIZATION
• TRANSCRIPTION FACTORS
• MULTIPLE-MYELOMA
• GASTRIC-CANCER

The aim of our meta-analysis was to assess the association between NFKB1 -94ins/delATTG promoter polymorphism and cancer risk. Eleven studies that included data from 2,743 cases and 2,195 controls were identified. When all groups were pooled, we did not detect the association between NFKB1 -94ins/delATTG promoter polymorphism and cancer risk. In the subgroup analysis, we detected the association of NFKB1 -94ins/delATTG promoter polymorphism with cancer in Caucasian population. The association also was found in Asian population. This meta-analysis demonstrates the association of NFKB1 -94ins/delATTG promoter polymorphism with cancer in Caucasian and Asian populations, and this association is ethno-specific.</.

• 出版日期2011-1
• 单位安徽医科大学; 南通大学