A program to analyse optical coherence tomography images of the ciliary muscle

作者：Laughton Deborah S; Coldrick Benjamin J; Sheppard Amy L; Davies Leon N^*

来源：Contact Lens and Anterior Eye, 2015, 38(6): 402-408.

DOI：10.1016/j.clae.2015.05.007

• Accommodation
• AS-OCT
• Ciliary muscle
• Presbyopia

Purpose: To describe and validate bespoke software designed to extract morphometric data from ciliary muscle Visante Anterior Segment Optical Coherence Tomography (AS-OCT) images.
Method: Initially, to ensure the software was capable of appropriately applying tiered refractive index corrections and accurately measuring orthogonal and oblique parameters, 5 sets of custom-made rigid gas-permeable lenses aligned to simulate the sclera and ciliary muscle were imaged by the Visante AS-OCT and were analysed by the software. Human temporal ciliary muscle data from 50 participants extracted via the internal Visante AS-OCT caliper method and the software were compared. The repeatability of the software was also investigated by imaging the temporal ciliary muscle of 10 participants on 2 occasions.
Results: The mean difference between the software and the absolute thickness measurements of the rigid gas-permeable lenses were not statistically significantly different from 0 (t=1.458, p = 0.151). Good correspondence was observed between human ciliary muscle measurements obtained by the software and the internal Visante AS-OCT calipers (maximum thickness t=0.864, p = 0.392, total length t=0.860, p = 0.394). The software extracted highly repeatable ciliary muscle measurements (variability <= 6% of mean value).
Conclusion: The bespoke software is capable of extracting accurate and repeatable ciliary muscle measurements and is suitable for analysing large data sets.

• 出版日期2015-12