A tale from TGF-beta superfamily for thymus ontogeny and function

作者:Jurberg Arnon Dias*; Vasconcelos Fontes Larissa; Cotta de Almeida Vinicius
来源:Frontiers in Immunology, 2015, 6: 442.
DOI:10.3389/fimmu.2015.00442

摘要

Multiple signaling pathways control every aspect of cell behavior, organ formation, and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-beta/bone morphogenetic protein ligands to address thymus morphogenesis and function in T cell differentiation. Recent findings on a role of GDF11 for reversing aging-related phenotypes are also discussed.

  • 出版日期2015-9-10