No long-term impairment of cerebral autoregulation after preeclampsia

作者：Janzarik Wibke G^*; Gerber Ann Kathrin; Markfeld Erol Filiz; Sommerlade Linda; Allignol Arthur; Reinhard Matthias

来源：Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health, 2018, 13: 171-173.

DOI：10.1016/j.preghy.2018.06.009

• Preeclampsia
• HELLP-syndrome
• Cerebral autoregulation
• Cerebrovascular risk

Introduction: Preeclampsia is a pregnancy-related hypertensive disorder with strongly impaired cerebral autoregulation in the acute stage. A history of preeclampsia is an independent cardiovascular and cerebrovascular risk factor. It is unclear whether impaired cerebral autoregulation persists after preeclampsia and thus contributes to the known increased cerebrovascular morbidity.
Methods: Using transcranial Doppler, we compared cerebral hemodynamics and dynamic cerebral autoregulation of 25 women with a history of severe preeclampsia and 25 healthy mothers, on average 2-3 years postpartum. Mean arterial blood pressure (MAP) and cerebral blood flow velocities (CBFV) in the middle and posterior cerebral artery were recorded at rest, dynamic cerebral autoregulation was assessed via transfer function phase and gain between oscillations of CBFV and MAP during regular breathing at 0.1 Hz.
Results: MAP and body mass index were higher in former preeclamptic women compared with healthy mothers (p-value < 0.001 and 0.006, respectively). CBFV in the middle cerebral artery was slightly increased in former preeclamptic women compared with healthy mothers (p-value 0.004), intima-media thickness (IMT) of the common carotid artery was higher by trend (p-value 0.065). Dynamic cerebral autoregulation was not impaired in women with a history of preeclampsia, phase even tended to be higher than in healthy mothers.
Conclusion: Dynamic cerebral autoregulation is not persistently impaired in women after severe preeclampsia. Long-term cerebrovascular changes rather result from a higher incidence of cerebrovascular risk factors in women with a history of preeclampsia.

• 出版日期2018-7