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摘要
Ag support on silica has been used as an effective heterogeneous catalyst for the facile synthesis of chloro-8-substituted-9H-purine derivatives via the one-pot reaction of 6-chloro-pyrimidines and substituted acids. The title compounds were formed as excellent yields with short reaction time under eco-friendly conditions. The prepared catalyst (Ag/SiO2) can be reused for a number of times with insignificant loss in its activity. This route has the advantage of being a cost-effective, readily available, easy workup procedure.
- 出版日期2016-1
