An overview of the chemistry and biology of reactive aldehydes

作者：Fritz Kristofer S; Petersen Dennis R^*

来源：Free Radical Biology and Medicine, 2013, 59: 85-91.

DOI：10.1016/j.freeradbiomed.2012.06.025

• Lipid peroxidation
• Reactive aldehyde
• 4-Hydroxynonenal

The nonenzymatic free radical generation of reactive aldehydes is known to contribute to diseases of sustained oxidative stress including rheumatoid arthritis, atherosclerosis, neurodegeneration, and a number of liver diseases. At the same time, the accumulation of lipid electrophiles has been demonstrated to play a role in cell signaling events through modification of proteins critical for cellular homeostasis. Given the broad scope of reactivity profiles and the ability to modify numerous proteomic and genomic processes, new emphasis is being placed on a systems-based analysis of the consequences of electrophilic adduction. This review focuses on the generation and chemical reactivity of lipid-derived aldehydes with a special focus on the homeostatic responses to electrophilic stress.

• 出版日期2013-6