Development of alpha-Tocopherol Acetate Nanoparticles: Influence of Preparative Processes

作者：Anais J P; Razzouq N; Carvalho M; Fernandez C; Astier A; Paul M^*; Astier A; Fessi H; Lorino A M

来源：Drug Development and Industrial Pharmacy, 2009, 35(2): 216-223.

DOI：10.1080/03639040802248798

• cigarette smoke toxicity
• vitamin E
• alpha-tocopherol acetate
• nanoparticles
• emulsification diffusion

We studied different methods of preparing alpha-tocopherol acetate (ATA) nanoparticles, which are to be used in targeting the lungs as aerosols in order to prevent cigarette smoke toxicity. Poly-(lactide) nanoparticles were prepared using nanoprecipitation and solvent evaporation techniques, which produced, respectively, too small and too large nanoparticles to be aerosolized. The emulsification-diffusion method produced 2 months stable nanoparticles with a size between (500-700 nm). Increasing ATA concentration (1-7 mg/mL) induced a decrease in the association rate (97-93%) and in the adsorbed ATA rate (7-4.5%), which was associated with variations of Zeta potentials (-27.5 to -24.3 mV) and decrease in polymeric wall thickness and density.

• 出版日期2009