Gold Nanoparticles Carrying Diatomic Molecules (O-2 and CO) in Aqueous Solution

作者：Karasugi Keiichi; Kitagishi Hiroaki; Kano Koji^*

来源：Chemistry-An Asian Journal, 2011, 6(3): 825-833.

DOI：10.1002/asia.201000756

• bioinorganic chemistry
• carbon monoxide
• cyclodextrins
• gold
• nanoparticles

Gold nanoparticles (AuNPs) prepared by citrate reduction of aurochloric acid (HAuCl4) were functionalized by tris(4-sulfonatophenyl)porphinatoiron(III) (Fe(III)P2) and poly(ethylene glycol) with thiolated arms (PEG-SH). Fe(III)P2 on the AuNP surface existed as its mu-oxo dimer, which was reduced by Na2S2O4 to yield monomeric Fe(II)P2. Fe(II)P2-bearing AuNPs were further functionalized through inclusion of two sulfonatophenyl groups of Fe(II)P2 by a per-O-methylated beta-cyclodextrin dimer with a pyridine linker (Py3CD) to obtain AuNPs capable of carrying diatomic molecules in the body. The resulting AuNPs (hemoCD-AuNPs) bound O-2 as well as CO in an aqueous solution. Although a noncolloidal 1:1 complex of 5,10,15,20-tetrakis(4-sulfonatophenyl)porphinatoiron(II) and Py3CD injected into the femoral vein of a rat was rapidly excreted in the urine, no excretion was observed with ferric hemoCD-AuNPs, which were gradually accumulated in the spleen and liver of a rat. These results suggest that hemoCD-AuNPs can be used as a carrier of diatomic molecules such as O-2 and CO in vivo.

• 出版日期2011-3-1