Differences in Neural Correlates of Speech Perception in 3 Month Olds at High and Low Risk for Autism Spectrum Disorder

作者：Edwards Laura A; Wagner Jennifer B; Tager Flu**erg Helen; Nelson Charles A

来源：Journal of Autism and Developmental Disorders, 2017, 47(10): 3125-3138.

DOI：10.1007/s10803-017-3222-1

• Autism spectrum disorders
• Near infrared spectroscopy
• Speech processing
• Infancy
• Endophenotype
• Language

In this study, we investigated neural precursors of language acquisition as potential endophenotypes of autism spectrum disorder (ASD) in 3-month-old infants at high and low familial ASD risk. Infants were imaged using functional near-infrared spectroscopy while they listened to auditory stimuli containing syllable repetitions; their neural responses were analyzed over left and right temporal regions. While female low risk infants showed initial neural activation that decreased over exposure to repetition-based stimuli, potentially indicating a habituation response to repetition in speech, female high risk infants showed no changes in neural activity over exposure. This finding may indicate a potential neural endophenotype of language development or ASD specific to females at risk for the disorder.

• 出版日期2017-10