Novel biflavone diglycosides and biological activity of Jatropha multifida leaves

作者：Marzouk M S^*; Moharram F A; Haggag E G; El Batran S M; Mahmoud I I; Ibrahim R R

来源：Chemistry of Natural Compounds, 2012, 48(5): 765-770.

DOI：10.1007/s10600-012-0377-z

• Jatropha multifida
• HR-ESI-MS
• biapigenin di-C-glucoside
• analgesic
• anti-inflammatory
• antihypertensive

Chromatographic separation of the 80% aqueous methanol extract (AME) of Jatropha multifida Linn. leaves has yielded three novel biapigenin di-C-glucosides, i.e., 6,6aEuro(3)-di-C-beta-glucopyranosyl-methylene-(8,8aEuro(3))biapigenin (7), 3,6aEuro(3)-di-C-beta-glucopyranosyl-methylene-(6,8aEuro(3))-biapigenin (8), and 6,6aEuro(3)-di-C-beta-glucopyranosyl-methylene-(3,8aEuro(3))-biapigenin (9), named jatrophenols I-III. In addition, seven known polyphenolic metabolites were identified as apigenin 7-O-beta-neohespredoside (1), ferulic acid (2), quercetrin (3), vicinin-II (4), isoorientin (5), vitexin (6), and luteolin (10) for the first time from this species. The AME of the plant was reported for the first time to have significant analgesic, anti-inflammatory, and antihypertensive effects.

• 出版日期2012-11