Determination of a novel diacylglycerol acyltransferase 1 inhibitor, 2-[4-(4-{5-[2-phenyl-5-(trifluoromethyl) oxazole-4-carboxamido]-1H-benzo[d]imidazol-2-yl} phenyl) cyclohexyl] acetic acid (KR-69232) in rat plasma using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study

作者：Seo Hyewon; Choi Sung Heum; Kwak Eun Young; Zheng Zhi; Kwak Hyun Jung; Ahn Jin Hee; Lee Yong Moon; Ahn Sung Hoon; Bae Myung Ae; Song Jin Sook^*

来源：Biomedical Chromatography, 2014, 28(3): 324-326.

DOI：10.1002/bmc.3053

• DGAT-1 inhibitor
• LC-MS
• MS
• pharmacokinetics
• method validation

A liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of KR-69232, a diacyltransferase 1 inhibitor, in rat plasma. KR-69232 in the concentration range of 0.004-4 mu g/mL was linear. The intra-and inter-day precision and accuracy were acceptable (%26lt;20%). KR-69232 was stable under various storage and handling conditions. The method was applied successfully in a pharmacokinetic study of KR-69232 in rats.

• 出版日期2014-3