A new ketosteroid from red alga Acanthophora spicifera

作者：Shi Dayong^*; Guo Shuju; Fan Xiao

来源：Chinese Journal of Oceanology and Limnology, 2011, 29(3): 674-678.

DOI：10.1007/s00343-011-0183-7

• red alga
• Acanthophora spicifera (Vahl.) Boergesen
• steroids
• cytotoxic activity

A new ketosteroid, along with six known steroids, was isolated from the ethanolic extracts of red alga Acanthophora spicifera (Vahl.) Boergesen. The structures, identified using chemical and spectroscopic methods including 2D NMR, were: (1) 22-hydroxy-5 alpha-cholest-3,6-dione, (2) 6-hydroxycholest-4-ene-3-one, (3) cholest-4-ene-3,6-dione, (4) cholest-5-ene-3 beta-ol, (5) 5 alpha-cholestane-3,6-dione, (6) beta-Sitosterol and (7) Saringosterol. The MTT method was used to test the cytotoxicity of the compounds against the human cancer cell lines, HCT-8, Bel-7402, BGC-823, A549 and HELA. Compounds 1, 2, 3 and 5 showed moderate cytotoxic activity against human cancer cell lines.

• 出版日期2011-5
• 单位中国科学院海洋研究所