New Antibacterial Bagremycins F and G from the Marine-Derived Streptomyces sp ZZ745

作者：Zhang, Di; Shu, Chenyan; Lian, Xiaoyuan^*; Zhang, Zhizhen^*

来源：Marine Drugs, 2018, 16(9): 330.

DOI：10.3390/md16090330

• Streptomyces sp
• ZZ745
• bagremycin F
• bagremycin G
• antibacterial activity

As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F (1) and G (2), were isolated from a marine actinomycete Streptomyces sp. ZZ745. The structures of these compounds were determined by means of NMR spectroscopic analysis, HRESIMS data, and optical rotation. Both bagremycins F (1) and G (2) showed antibacterial activity against Escherichia coli, with MIC values of 41.8 and 61.7 M, respectively.

• 出版日期2018-9
• 单位浙江大学